Volume 1, Issue 2 (Autumn & Winter 2007)                   IJPBS 2007, 1(2): 23-27 | Back to browse issues page

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Mokhber N, Talaei A. Comparing the Efficacy of add-on Nortryptiline With Triiodothyronine in the Management of Citalopram-Resistant Depression. IJPBS. 2007; 1 (2) :23-27
URL: http://ijpbs.mazums.ac.ir/article-1-136-en.html
Abstract:   (9613 Views)
Objective: To manage a treatment resistant depression, clinicians may add a second medicationto the first antidepressant drug. The aim of the current research was to study the outcome of augmentation of citalopram with nortryptiline or triiodothyronine in a randomized clinical trial.
Methods: We selected 48 adult outpatients with a diagnosis of non-psychoticmajor depressive disorder who had not responded to 12 weeks citalopram therapy (40 mg perday). They were randomly allocated to two groups. One group received nortryiptiline (at a dose of upto 150 mg per day) and the other triiodothyronine (T3) (at a dose of up to 50 µg per day). The remission of depression was defined as a score of 7or less on the 17-item Hamilton Rating Scale for Depression(HRSD-17).
Results: After 8 weeks, the nortriptyline group had a higher remission rate (33.33 %) than the triiodothyroninegroup (17.64%). The nortriptyline group, however, had a higher dropout ratedue to experiencing more side effects.
Conclusion: Augmentation of citalopram with nortryptiline seems to be effective in the management of treatment resistant depression. However, one should strike a balance between the efficacy and the tolerability of this approach, as there is a higher chance of experiencing side effects by the patients.
Full-Text [PDF 112 kb]   (1436 Downloads)    
Type of Study: Research | Subject: Psychiatry
Received: 2012/05/28 | Accepted: 2014/01/6 | Published: 2014/01/6

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