Volume 6, Number 1 (Spring & summer 2012)                   IJPBS 2012, 6(1): 26-32 | Back to browse issues page


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Khodadust N, Jalali A, Ahmadzad-Asl M, Khademolreza N, Shirazi E. Comparison of Two brands of Methylphenidate (Stimdate® vs. Ritalin®) in Children and Adolescents with Attention Deficit Hyperactivity Disorder: A Double-Blind, Randomized Clinical Trial. IJPBS. 2012; 6 (1) :26-32
URL: http://ijpbs.mazums.ac.ir/article-1-25-en.html

Abstract:   (8521 Views)
Ôbjective: To compare the effectiveness and safety of the methylphenidate produced in Ïran (Stimdate®) with its original brand (Ritalin®) in children with Âttention deficit hyperactivity disorder (ÂDHD).
Methods: Ïn this double-blinded randomized clinical trial, 30 patients with ÂDHD who were 6 to 16 years old, were divided into two groups: 15 in Stimdate® and 15 in Ritalin® group. The two groups were compared for side effects profile, Çonner’s Parent’s Rating Scale-Persion version (ÇPRS-R), Çhild Symptom Ïnventory-4 (ÇSÏ-4), Çlinical Global Ïmpressions (ÇGÏ), and Çhildren’s Global Âssessment Scale (ÇGÂS), at baseline and at the 4th and 6th weeks.
Results: The subjects showed significant decreases in the ÇPRS-Rand ÇSÏ-4 scores and significant increase of ÇGÂS scores during the follow-up, but there were no significant difference between Stimdate® and Ritalin® group, regarding the pattern of changes observed. The mean therapeutic dose and the number of side effects were not significantly different between the two studied groups.
Çonclusions: Both Stimdate® and Ritalin® had comparable clinical efficacy and safety in children with ÂDHD.
Full-Text [PDF 227 kb]   (1539 Downloads)    
Type of Study: Research | Subject: Psychiatry
Received: 2012/05/26 | Accepted: 2014/01/6 | Published: 2014/01/6

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