Volume 7, Number 2 (10-2013)                   IJPBS 2013, 7(2): 11-15 | Back to browse issues page


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Mirsepassi Z, Mazinani R, Fadai F, Alibeigi N, Nazeri-Astaneh A. Topiramate Add-on Lithium Carbonate for Treatment of Acute Mania. IJPBS. 2013; 7 (2) :11-15
URL: http://ijpbs.mazums.ac.ir/article-1-286-en.html

Resident Department of Psychiatry, Razi Psychiatric Hospital, University of Social Welfare and Rehabilitation Sciences, Tehran, Iran.
Abstract:   (6897 Views)
Objective: The purpose of this study was to evaluate the effect of adjunctive topiramate in treating acute mania. Methods: In this study which was a double-blinded randomized clinical trial, 46 bipolar patients in manic episode, were treated with lithium carbonate and topiramate versus lithium carbonate and placebo and treatment responses were assessed by Young Mania Rating Scale (YMRS) weekly. Results: In both intervention and control groups, YMRS score had significant decline after 8 weeks (p < 0.001), but there was no statistically significant difference between the two groups (p = 0.419). The highest score decline was after two weeks. YMRS score at baseline did not have statistically significant difference between the intervention and control groups (p = 0.709). Conclusions: This study failed to show antimanic efficacy of adjunctive topiramate in the treatment of those with acute manic
Full-Text [PDF 57 kb]   (1179 Downloads)    
Type of Study: Review | Subject: Psychiatry
Received: 2013/10/7 | Accepted: 2013/10/7 | Published: 2013/10/7

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