Volume 2, Number 2 (Autumn & Winter 2008)                   IJPBS 2008, 2(2): 35-40 | Back to browse issues page


XML Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Manteghiy A, Shakeri M T, Koohestani L, Salari E. Beneficial Antipsychotic Effects of Omega-3 Fatty Acids Add-On Therapy for the Pharmacological Management of Patients With Schizophrenia. IJPBS. 2008; 2 (2) :35-40
URL: http://ijpbs.mazums.ac.ir/article-1-119-en.html

Abstract:   (15251 Views)
Ôbjective: Ït has been shown that serum and red blood cells’ level of Ômega-3 fatty acids are low in people with schizophrenia. Many studies have, therefore, attempted to explore the beneficial effects of these substances in the management of Schizophrenia. However, the outcomes of the previous studies have not been clear cut. The present study is an attempt to retest this hypothesis by eliminating some of the limitations of the previous studies.
Methods: Ïn a prospective double blind placebo-controlled clinical trial, 85 inpatients with schizophrenia randomly assigned to either risperidone plus Ômega-3 or risperidone plus placebo. Âfter a washout period, 44 patients received 2-8 mg/day of risperidone plus placebo and 43 patients received risperidone plus 3 gr/day of Ômega-3 for 6 weeks. The treatment effect was calculated by Friedman, Mann Whitney and t test. There were no significant differences between groups in age, sex, education, duration of illness and the number of previous hospitalizations.
Results: There were no statistically significant differences in the scores of Positive and Negative Syndrome Scale between two groups at weeks 0, 3 and 6 and for the whole duration of the study.
Çonclusion: Ïn our study, Ômega-3 fatty acids had no superiority to placebo in reducing the positive and negative symptoms of schizophrenia. However, due to a short duration of our study, we recommend that more long term clinical trials are needed in order to develop a better understanding of the therapeutic effects of the Ômega-3 fatty acids in the pharmacological management of schizophrenia.
Full-Text [PDF 103 kb]   (1079 Downloads)    
Type of Study: Research | Subject: Psychiatry
Received: 2012/05/28 | Accepted: 2014/01/6 | Published: 2014/01/6

Add your comments about this article : Your username or email:
Write the security code in the box

Send email to the article author


© 2015 All Rights Reserved | Iranian Journal of Psychiatry and Behavioral Sciences

Designed & Developed by : Yektaweb